For many older adults, Depression is more than just sadness. It can be persistent, debilitating, and resistant to standard treatment. In fact, a significant number of adults over the age
When Antidepressants Stop Working: An Update on “Poop Out”
Antidepressants have brought relief to millions of people struggling with major depressive disorder (MDD). They can restore energy, stabilize mood, and allow patients to reclaim parts of their lives that
Does Ketamine Improve Quality of Life for People with Depression?
When you hear the word “ketamine,” you might think of club drugs or even anesthesia. But in recent years, ketamine—and its close cousin, esketamine (Spravato)—has been receiving much attention in
Depression and Cardiovascular Disease
Depression and cardiovascular disease (CVD) are two of the most pervasive and disabling health conditions globally—and mounting evidence shows that they are deeply interconnected. Heart disease continues to be the
Breaking the Cycle of Treatment-Resistant Depression: Real-World Lessons from Europe
Treatment-resistant Depression (TRD) poses a significant challenge in mental health care. Despite the availability of various antidepressant therapies, a substantial subset of patients fails to achieve response or remission, leading
Enhancing Depression Treatment: The Synergistic Potential of TMS and Antidepressants
Major Depressive Disorder (MDD) stands as a leading cause of disability worldwide, affecting millions and imposing significant personal and societal burdens. Traditional treatment modalities, primarily pharmacotherapy with antidepressants, have shown
Can Exercise Treat Depression?
Depression: A Growing Global Challenge Depression is one of the world’s leading causes of disability, affecting over 280 million people worldwide. Traditional treatments—such as antidepressants and psychotherapy—help many, but they’re
An Important Recent Study On Treatment-Resistant Depression: Population-Wide TRD Research
Treatment-Resistant Depression (TRD) remains a significant issue for many people and TRD research on a large population can help build scientific understanding that can lead to more effective treatment. A
What is the Serotonin Theory of Depression?
Investigating the catalysts of and biological mechanisms behind major depressive disorder (MDD) has proven an ongoing challenge for scientists and clinicians for decades. As various theories have gained and lost
What is D-Cycloserine: How to Repurpose this Antibiotic
Innovation in modern medicine doesn’t always necessitate the invention of new drugs; in some cases, existing medications may be repurposed. One such interesting case is how the antibiotic D-cycloserine might